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#17 CTSNet Beat Podcast : LAAOS III Trial, Randomized Trial of Left Atrial Appendage Occlusion, and Meta-Analysis Comparing Revascularization and Medical Treatment

June 7, 2021

The Beat episode, hosted by Patrick Myers, cardiac surgeon at the University of Lausanne and Geneva, Switzerland, focuses on three recent publications, presented at the ACC21 and EuroPCR meetings. First, Dr Myers discusses the LAAOS III trial, a practice-changing multicenter prospective randomized trial of left atrial appendage occlusion during cardiac surgery. He then dives into a meta-analysis comparing revascularization and medical treatment, covering 20’000 patients from 25 RCTs. Dr Myers then reviews a UK study on the impact of the COVID-19 pandemic on SAVR and TAVI volumes. He finally notes to not miss the guest editor series lead by Mark Gerdish, on surgery for atrial fibrillation. For more information on this episode’s topics, links to the articles are provided below:

1. Whitlock RP, Belley-Cote EP, Paparella D, Healey JS, Brady K, Sharma M, Reents W, Budera P, Baddour AJ, Fila P, Devereaux PJ, Bogachev-Prokophiev A, Boening A, Teoh KHT, Tagarakis GI, Slaughter MS, Royse AG, McGuinness S, Alings M, Punjabi PP, Mazer CD, Folkeringa RJ, Colli A, Avezum Á, Nakamya J, Balasubramanian K, Vincent J, Voisine P, Lamy A, Yusuf S, Connolly SJ; LAAOS III Investigators. Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. N Engl J Med. 2021 May 15. doi: 10.1056/NEJMoa2101897.
2. Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, Valgimigli M, Curzen N, Kandzari DE, Bonaca MP, Brouwer M, Umińska J, Jaguszewski MJ, Raggi P, Waksman R, Leon MB, Wijns W, Andreotti F. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis. Eur Heart J. 2021 May 18:ehab246. doi: 10.1093/eurheartj/ehab246.
3. Martin GP, Curzen N, Goodwin AT, Nolan J, Balacumaraswami L, Ludman PF, Kontopantelis E, Wu J, Gale CP, de Belder MA, Mamas MA. Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. Circ Cardiovasc Interv. 2021 May;14(5):e010413. doi: 10.1161/CIRCINTERVENTIONS.120.010413.
4. Gerdish M, La Meir M, McCarthy P, Ad N. Guest Editor Series Webinar: surgical atrial fibrillation – what we must do and what we can do. https://www.ctsnet.org/article/guest-editor-series-webinar-surgical-atrial-fibrillation-what-we-must-do-and-what-we-can-do

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